Frequently asked questions.

exosmart is a CE-MDR Class IIa medical device for concentrating blood components. It processes the patient’s platelet-rich plasma (PRP) and platelet-poor plasma (PPP) together through hollow-fibre ultrafiltration.

The starting material comes from the patient’s own blood. The plasma is prepared and concentrated for that patient.

PRP supplies platelets and their associated mediators. PPP contributes plasma containing circulating signals, carrier and regulatory proteins, and matrix-forming proteins. These components are also present in the plasma surrounding platelets in PRP. exosmart concentrates these plasma fractions together.

Centrifugation prepares the plasma fractions. exosmart adds a hollow-fibre concentration step that processes PRP and PPP together. The distinction is the starting material and the concentration workflow; the resulting preparation includes platelet and wider plasma components.

The concept describes five overlapping biological layers: vesicles, platelets, soluble signals, carrier and regulatory proteins, and matrix-forming components. “Complete” refers to this biological breadth.

It is a concentrated autologous plasma preparation. Extracellular vesicles are part of a broader composition that also includes platelets, soluble mediators and plasma proteins. The workflow concentrates these components together rather than purifying a single vesicle population.

The workflow has four stages: prepare the plasma, assemble the device circuit, concentrate the combined PRP and PPP, and collect the final preparation. The preparation page brings the demonstration films and equipment checklist together.

The standard workflow shown on this website starts with approximately 30 mL of combined PRP and PPP and produces approximately 6 mL. Preparation materials also describe 25–30 mL input and 6–7 mL output; these are workflow-dependent ranges, not fixed yields. Use the current device instructions for your preparation workflow.

The hollow-fibre concentration step takes approximately 3–5 minutes. Blood collection, centrifugation, device set-up and final collection add to the appointment time; centrifugation follows the selected plasma preparation system.

Use a validated plasma preparation system that provides the required combined PRP and PPP volume. Follow that system’s collection and centrifugation instructions. Tell our clinical team which system you use so they can review the preparation workflow with you.

Yes. Each sterile exosmart kit is intended for one patient and one procedure. Check packaging and expiry before use, maintain aseptic technique and dispose of used components through the clinic’s clinical-waste process.

The preparation page contains the original film and links to the UMA Academy recordings. The manufacturer’s Instructions for Use provide the device operating sequence. Request the current document for your market and language through our documentation team.

Third-party NTA analysis reported 5.0 × 10¹²–3.0 × 10¹³ particles/mL across four analysed preparations. The Science page shows the sample results and methods alongside the laboratory context.

NTA measures particle concentration and size distribution. It does not identify every counted particle as an exosome. Microscopy and EV-associated marker analysis provide complementary information about the vesicular component.

These are EV-associated markers examined as part of the analytical characterisation. Marker findings are read together with morphology, particle measurements and the other laboratory methods.

Yes. Testing of the final preparation includes EGF, PDGF, VEGF and TGF-β1. The system page provides the reported concentrations, units, donor context and assay notes.

The Science page presents device-related clinical observations with their sample sizes, treatment schedules, measured outcomes and follow-up. Specialty Evidence Compendia place these findings alongside the wider literature.

Yes. Tell us which analysis you need—for example NTA, microscopy, EV-associated markers or growth-factor testing—and the purpose of your review. The documentation team can direct you to the relevant material.

The current application pages cover orthopaedics and sports medicine, dermatology and aesthetics, and hair and scalp. For another specialty, contact the clinical team for the available evidence and educational material.

The preparation is made for use during the clinical visit. Some device-related observational studies used a single treatment followed by scheduled review. The clinician sets the treatment plan and any repeat treatment according to the condition, clinical findings and follow-up.

Assessment follows the treatment objective: pain and function in musculoskeletal care, clinical and imaging measures in skin care, or standardised photography and trichoscopy in hair care. Baseline records and planned follow-up make changes easier to evaluate.

Aftercare should match the treated area, procedure and patient. The specialty handbooks include treatment planning and follow-up material. Ask the treating clinic for your own written aftercare instructions, and contact the clinical team for professional guidance.

Send your country or city and the type of treatment you are considering. The team can help direct your enquiry to a clinical contact. The treating clinician assesses suitability and discusses the procedure, expected course and treatment cost.

Yes. exosmart Academy provides professional education, and the team can arrange preparation or specialty training. Include your country, specialty, team size and the topics you want to cover.

Language availability varies by document. Tell us the handbook, brochure or device document you need and your preferred language. We will direct you to the available version.

Contact the team with your country and organisation. We can confirm the relevant distribution contact, product availability and documentation for your market.

Tell us your territory, organisation, clinical specialties and current distribution activity. The team will discuss market coverage, training, local support and commercial terms with you.

The form prepares a message in your email app for you to review and send. You can also copy the prepared message or contact the team directly by email or WhatsApp.