The science and clinical use of the preparation in skin quality, photoageing and aesthetic dermatology.
THE TISSUE & THE PREPARATION
Plasma components involved in skin repair
Epidermis · dermal matrix · subcutaneous tissue
Fibroblasts, extracellular matrix, vascular signalling and cell communication all contribute to the skin’s response. Hydration, pigmentation, surface features and dermal structure each require specific assessment.
Our approach keeps platelet-associated signals with vesicles, soluble mediators, carrier proteins and matrix-forming components from the patient’s plasma. The clinical handbook covers patient assessment, preparation, treatment planning, aftercare and follow-up.
Cell communication
Vesicles and soluble factors participate in communication between cells.
Dermal environment
Carrier proteins influence signal availability; matrix components contribute to the tissue environment.
Clinical measurement
Photography, skin-quality measures and ultrasound can track different aspects of the response.
CLINICAL FOCUS
Areas covered in the handbook
01
Skin quality & photoageing
Face, neck and décolletage, with attention to fine lines, surface features and the patient’s priorities.
02
Scars & pigment
Dedicated teaching considers the condition, skin phenotype, treatment history and the place of combination care.
03
Treatment planning
Assessment, procedural planning, aftercare and consistent photography are covered together in the clinical handbook.
EXOSMART OBSERVATIONAL SERIES · 10 PATIENTS · 12 MONTHS
A single treatment, followed over time.
In Dr Montse Ponga Manso’s prospective series, 10 patients received one treatment and were followed by ultrasound. Mean subepidermal low-echogenic band thickness changed from 0.143 mm at baseline to 0.049 mm at one year. This single-arm series used 60 mL blood, approximately 20 mL plasma and approximately 8 mL output. The handbook presents the ultrasound findings and follow-up.
The intervals below are educational follow-up guidance, not the schedule of a specific study. Record a baseline and adapt follow-up to the condition, procedure and patient. Refer to the specialty handbook for treatment planning.
Before treatment
Agree the skin-quality objective and record standardised baseline images.
4–6 weeks
Review the selected skin measures after the early procedural effects settle.
Around 3 months
Compare skin-quality measures with baseline and discuss the patient’s priorities.
Ongoing
Plan further treatment around the documented response and remaining target.
What to record Photography · skin quality · hydration · ultrasound
PROFESSIONAL EDUCATION
EXOSMART ACADEMY · OCTOBER 2026
The clinical handbook.
Biology, clinical evidence, assessment and follow-up for dermatology.
Written by Mihail Blagoev, co-founder of exosmart and Global Regenerative Group. Use the companion Evidence Compendium for study detail and the Pocket Card for a concise clinical reference.
