Advancing Knowledge in Exosome Science
At exosmart™, we are committed to furthering understanding and promoting innovation in the realm of exosome science. Our publication section contains a wealth of research studies, supporting the therapeutic potential and versatility of our autologous platelet exosomes.
Our exosomes publications cover a broad range of topics, including:
- Characterization of Exosomes: Understand the fundamental properties and functions of these nano-sized vesicles that hold promising potential for numerous clinical applications.
- Exosomes in Aesthetic and Regenerative Medicine: Learn about the potential of exosomes in improving aesthetic outcomes and promoting tissue regeneration.
- Platelet-Derived Exosomes: Discover how exosomes, particularly those derived from platelets, can contribute to hemostasis and protect against the development of hemorrhagic shock.
- Exosomes in Osteoarthritis Treatment: Delve into studies demonstrating how platelet-derived exosomes may alleviate symptoms of knee osteoarthritis by promoting chondrocyte proliferation and inhibiting apoptosis.
- Exosomes and Vascular Health: Explore research illustrating the role of platelet-derived exosomes in enhancing vasoregenerative potential and inducing angiogenesis.
- Exosomes in Neural and Bone Health: Understand how exosomes may promote neural stem cell proliferation, survival, and differentiation, as well as osteoinduction of mesenchymal stromal cells.
Through our commitment to research and development, exosmart™ is continuously expanding the frontiers of exosome science. Our publications provide essential insights into the potential applications of exosomes across a diverse array of medical fields.
Peer-Reviewed Research Supporting Autologous Exosome Therapy
The exosmart™ system is supported by extensive peer-reviewed scientific literature demonstrating the therapeutic potential of platelet-derived extracellular vesicles (pEVs) in regenerative medicine.
Featured Research:
Orthopedics & Musculoskeletal Regeneration
Exosomes from platelet-rich plasma alleviate knee osteoarthritis
Liu et al., J Orthop Surg Res, 2019
Demonstrates superior efficacy of PRP-derived exosomes compared to activated PRP in promoting chondrocyte proliferation and inhibiting apoptosis through Wnt/β-catenin signaling pathway.
Platelet-derived extracellular vesicles promote osteoinduction
Antich-Rosselló et al., Bone Joint Res, 2020
Shows dose-dependent osteogenic differentiation of mesenchymal stromal cells when treated with platelet EVs, supporting applications in bone regeneration.
Vascular Regeneration & Angiogenesis
Platelet microparticles induce angiogenesis and vascular repair
Multiple studies demonstrate the pro-angiogenic effects of platelet-derived vesicles, essential for tissue healing and regeneration.
Enhanced vasoregenerative potential through platelet microparticles
Evidence supporting improved vascular repair mechanisms following injury through concentrated platelet-derived factors.
Cellular Biology & Characterization
Biological characteristics of platelet-derived extracellular vesicles
Spakova et al., Int J Mol Sci, 2021
Comprehensive review of isolation methods, molecular characterization, and therapeutic applications of platelet EVs.
Mechanisms of Action
Research consistently demonstrates that platelet-derived exosomes:
- Promote cellular proliferation and migration
- Modulate inflammatory responses
- Enhance angiogenesis and tissue vascularization
- Stimulate stem cell differentiation
- Provide sustained release of growth factors
Clinical Translation
These foundational studies provide the scientific rationale for exosmart™’s clinical applications across multiple therapeutic areas, supporting the transition from laboratory research to point-of-care regenerative medicine.
For access to specific publications or to discuss the scientific evidence, please contact our medical affairs team.
- exosmart- Autologous Platelets Exosomes
- Exosomes: Extracellular organelles important in intercellular communication
- The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine- A Comprehensive Review
- EXOSOMES NOVEL EFFECTORS OF HUMAN PLATELET LYSATE ACTIVITY
- Exosomes derived from platelet-rich plasma promote
- Platelet-derived- Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock
- Regulation of endothelial cell permeability by platelet-derived
- Activated Platelet-Derived Vesicles for Efficient Hemostatic Activity
- Microparticles-(Ectosomes)-Shed-by-Stored-Human-Platelets-Downregulate-Macrophages-and-Modify-the-Development-of-Dendritic-Cells
- Comparison-and-Investigation-of-Exosomes-Derived-from-Platelet-Rich-Plasma-Activated-by-Different-Agonists
- Platelet Extracellular Vesicles
- Platelet microvesicles in health and disease
- Isolation-of-Platelet-Derived-Exosomes-from-Human-Platelet-Rich-Plasma-Biochemical-and-Morphological-Characterization
- Platelet-derived-exosomes-and-atherothrombosis
- Platelet-Microparticles-Enhance-the-Vasoregenerative-Potential-of-Angiogenic-Early-Outgrowth-Cells-After-Vascular-Injury
- Platelet microparticles induce angiogenesis in vitro
- Platelet-derived-microparticles-induce-angiogenesis-and-stimulate-post-ischemic-revascularization
- Platelet Microparticles Promote Neural Stem Cell Proliferation, Survival and Differentiation
- Exosomes-derived-from-human-platelet-rich-plasma-prevent-apoptosis-induced-by-glucocorticoid-associated-endoplasmic-reticulum-stress-in-rat-osteonecrosis-of-the-femoral-head
- Platelet-Derived-Extracellular-Vesicles-for-Regenerative-Medicine
- Exosomes-derived-from-platelet-rich-plasma-administration-in-site-mediate-cartilage-protection-in-subtalar-osteoarthritis