The exosmart™ System: Advanced Point-of-Care Autologous Therapy
Revolutionary Ultrafiltration Technology
The exosmart™ system employs patented ultrafiltration technology that represents a paradigm shift in autologous biological preparation. Unlike traditional methods that isolate single components, our system captures and concentrates the complete regenerative milieu.
Key Technical Specifications
Processing Parameters
- Total Procedure Time: 20-30 minutes from blood draw to final product
- Concentration Time: 3-5 minutes active processing
- Input Volume: 60 mL whole blood → 30 mL plasma
- Output Volume: 6-7 mL therapeutic concentrate
- Concentration Factor: 5-fold volume reduction
Membrane Technology
- Molecular Weight Cutoff: 15 kDa
- Pore Size: <5 nm
- Recovery Efficiency: >85% particle retention
- Selectivity: Removes water and salts while retaining all therapeutic biomolecules
Validated Output Characteristics
Particle Concentration
- Up to 3×10¹³ particles per milliliter
- 136-fold higher concentration than reference standards
- <20% inter-batch variability ensuring reproducibility
Biological Components Retained
- Exosomes (30-150 nm): Primary signaling vesicles
- Platelets (70-95% recovery): Sustained growth factor release
- Growth Factors: Including VEGF, TGF-β, PDGF-BB (47% increase)
- Fibrin Network: Natural biological scaffold
- Cytokines: Immunomodulatory factors
Quality Validation
MISEV2023 Compliance
- 93.2% CD9 positivity confirming exosome enrichment
- Comprehensive characterization according to International Society for Extracellular Vesicles standards
- Validated potency markers for clinical efficacy
Advantages Over Traditional Methods
Regulatory Certification
CE-MDR Class IIa Medical Device
Certified for use in:
- Orthopedics
- Aesthetics
- Wound Care
- Ophthalmology
- Gynecology
- Surgery
Clinical Safety Profile
Initial clinical validation demonstrates:
- Zero adverse events in 30-patient trial
- 100% processing success rate
- 10/10 patient satisfaction scores
The exosmart™ system represents the evolution from inconsistent, single-component therapies to a standardized, comprehensive regenerative solution suitable for immediate clinical application.