Therapeutic Areas
A New Standard in Autologous Therapy: The Clinical Applications of exosmart™
The exosmart™ system is a CE-MDR Class 2a certified medical device, engineered to be a versatile, point-of-care platform for regenerative medicine. By concentrating the complete profile of a patient’s own exosomes, platelets, and growth factors, it provides a powerful tool for clinicians across a broad spectrum of medical specialties.
Explore the validated applications of our technology below.
A Hub of Certified Applications:
Orthopedics & Musculoskeletal System
The exosmart™ concentrate is used to address damage to the musculoskeletal system by delivering a potent anti-inflammatory and pro-regenerative product to the site of injury. The high concentration of growth factors (like TGF-β) and exosomes helps modulate inflammation within joints and stimulates resident cells like chondrocytes and tenocytes to repair damaged tissue. This approach aims to improve function and reduce pain in degenerative joint and tendon conditions.
- Primary Uses: Osteoarthritis, rotator cuff injuries, tendinopathies, muscle and ligament damage.
- Supporting Evidence: Studies show that platelet-derived extracellular vesicles can protect cartilage cells from apoptosis and promote matrix synthesis, suggesting a therapeutic role in conditions like osteoarthritis. (Ref: Int J Mol Sci, 2021)
- exosmart™ Clinical Trials: An active study is underway for Osteoarthritis (OA), alongside research into applications for intervertebral disc issues (“black disc injections”).
Surgery (Multi-Disciplinary Support)
The concentrate serves as a valuable adjunct in various surgical fields by preparing a patient’s own healing factors to be applied directly at the surgical site. The fibrin network in the product acts as a natural biological sealant and scaffold, holding growth factors at the site of repair to accelerate the natural healing process and reduce recovery time.
- Certified Surgical Fields:
- Facial and Odontostomatological Surgery: For dental implants, bone grafts, and soft tissue reconstruction.
- Neurosurgery: As an adjunct for procedures like spinal fusion.
- Cardiothoracic Surgery: To aid in sternal wound healing and reduce complications.
- Supporting Evidence: The application of biological growth factors to enhance fusion rates in spinal surgery is an area of active research, with PRP showing potential to stimulate the bone regeneration cascade. (Ref: J Orthop Surg Res, 2019)
Chronic Ulcers & Wound Care
This therapy provides a powerful tool for shifting a chronic, non-healing wound into a pro-healing state. It promotes robust angiogenesis (new blood vessel formation) to restore blood flow to damaged tissue, while growth factors stimulate the formation of new, healthy granulation tissue.
- Primary Uses: Diabetic foot ulcers, venous leg ulcers, pressure ulcers, and other acute or non-healing chronic wounds.
- Supporting Evidence: Research has demonstrated that PRP-derived exosomes accelerate re-epithelialization and wound closure in diabetic models by activating key healing pathways. (Ref: Theranostics, 2017)
- Exosmart™ Clinical Trials: A clinical study on wound healing applications is in progress.e
Aesthetic Medicine & Dermatology
A unified tool for rejuvenating both skin and hair. For skin, the therapy stimulates fibroblasts to produce new collagen and elastin, improving skin firmness, texture, and healing scars. For hair restoration, it delivers the necessary signals to awaken dormant follicles and improve scalp health by increasing blood flow and reducing micro-inflammation.
- Primary Uses: Facial rejuvenation, scar treatment, post-procedure healing, and Androgenetic Alopecia.
- Supporting Evidence: A recent 2024 review confirmed the growing evidence for PRP-derived exosomes in dermatology and wound healing. (Ref: J Cosmet Dermatol, 2024)
- exosmart™ Clinical Trials: Studies on hair loss and aesthetic applications for the face and body are currently in progress.
Ophthalmology
Prepared as autologous serum eye drops, the therapy is used to treat ocular surface diseases. The rich concentration of growth factors, vitamins, and lubricating proteins in the product helps reduce inflammation, promote the healing of corneal epithelial defects, and treat severe dry eye conditions.
- Primary Uses: Severe Dry Eye Disease, corneal ulcers, and support for other ocular surface pathologies as determined by a physician.
- Supporting Evidence: Autologous platelet-rich plasma eye drops have been shown to be an effective and safe treatment for severe dry eye disease and other persistent ocular surface disorders. (Ref: J Clin Med, 2021)
Gynecology
The use of autologous therapies in gynecology is an emerging field focused on addressing issues related to tissue atrophy and infertility. For infertility, Intrauterine Infusion of the concentrate is performed to improve endometrial receptivity by enhancing the uterine lining’s thickness and vascularity, creating a more favorable environment for embryo implantation.
- Primary Uses: Vulvar/vaginal rejuvenation, treatment of lichen sclerosus, and support for patients with recurrent implantation failure.
- Supporting Evidence: Preliminary studies on intrauterine infusion of platelet-derived products have shown promise in improving outcomes for patients with thin endometrium.
- exosmart™ Clinical Trials: A study focusing on applications in infertility is a key part of our research program.
